(−)-Linalool influence on the cerebral blood flow in healthy male volunteers revealed by three-dimensional pseudo-continuous arterial spin labeling

BACKGROUND Although aromatherapy is widely used, the pharmacology of the essential oils remains undiscovered. AIM The present study assessed the effect of (-)-linalool, the main contained material of lavender, on the brain function. MATERIALS AND METHODS Healthy male volunteers calculated the regional cerebral blood flow (CBF) before and after inhalation of (-)-linalool, and CBF changes were evaluated. RESULTS There were significant CBF reductions in the right superior temporal gyrus to insula, anterior cingulate cortex after inhalation. CONCLUSIONS The previous study detected the regulatory influence of (-)-linalool on the glutamatergic transmission. The effect of (-)-linalool on the ACC and insula would cause the sedative and anxiolytic activity.